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While seaweed
is more of a novelty in the typical
Western diet, save for an occasional
sushi dinner or bowl of miso soup, it’s
been a staple food in Japan, Korea and
China since ancient times. In Japan,
seaweed may account for more than 10% of
the diet, and 21 different types are
used in everyday cooking.1
Seaweed is
highly nutritious and provides a rich
source of micronutrients.2 However,
it also has powerful antiviral
properties and researchers are looking
into seaweed extracts as potential
treatments against SARS-CoV-2, the virus
that causes COVID-19.
Researchers
from the Center for Biotechnology and
Interdisciplinary Studies (CBIS) at
Rensselear Polytechnic Institute tested
the antiviral effectiveness of seaweed
extracts against SARS-CoV-2,3 with
promising results.
"We're
learning how to block viral infection,
and that is knowledge we are going to
need if we want to rapidly confront
pandemics," said lead researcher
Jonathan Dordick in a news release. "The
reality is that we don't have great
antivirals. To protect ourselves against
future pandemics, we are going to need
an arsenal of approaches that we can
quickly adapt to emerging viruses."6
Remdesivir is an antiviral
drug that has shown some promise in
treating COVID-19, however serious side
effects have been reported, including
kidney failure.8 With
the seaweed extracts, however, no
cellular toxicity was found, even at the
highest concentrations.
Robert
Linhardt, a Rensselaer professor who’s
collaborating with Dordick, said what’s
most intriguing is uncovering a
potential new way to treat an infection:10
"The
current thinking is that the COVID-19
infection starts in the nose, and either
of these substances could be the basis
for a nasal spray. If you could simply
treat the infection early, or even treat
before you have the infection, you would
have a way of blocking it before it
enters the body."
Because the
seaweed compounds can also be consumed
orally, they may also be beneficial for
addressing gastrointestinal infections,
according to Dordick. In fact, while the
drug remdesivir must be delivered
intravenously, the seaweed extracts
could be delivered through a nasal
spray, inhaler or orally. When taken
orally, seaweed fucoidans are considered
“Generally Recognized as Safe.”11
The seaweed
extracts appear to work against
SARS-CoV-2 via what’s known as a decoy
technique, which has previously been
used against dengue, Zika, influenza A
and other viruses. According to the
Rensselaer Polytechnic Institute in a
news release:12
“The spike
protein on the surface of SARS-CoV-2
latches onto the ACE-2 receptor, a
molecule on the surface of human cells.
Once secured, the virus inserts its own
genetic material into the cell,
hijacking the cellular machinery to
produce replica viruses.
But the
virus could just as easily be persuaded
to lock onto a decoy molecule that
offers a similar fit. The neutralized
virus would be trapped and eventually
degrade naturally.”
By binding
tightly to the spike protein of
SARS-CoV-2, seaweed’s sulfated
polysaccharides may act as decoys to
interfere with the spike protein binding
to the heparan sulfate co-receptor,
which could effectively deter viral
infection.13
Also worth
noting, separate research found that
anticoagulants such as heparin (found in
some species of seaweed) led to
better outcomes among hospitalized
COVID-19 patients. Intubated patients
who received heparin had a significantly
lower risk of mortality compared to
those who did not.14
“It is
unknown whether this is a result of
heparin’s anticoagulation alone, or to
some degree is an effect of its
anti-SARS-CoV-2 activity,” the featured
study researchers explained.15
While the
usage against SARS-CoV-2 is new, seaweed
extracts and polysaccharides including
carrageenan, alginate, fucan, laminaran
and naviculan have long been valued for
their antiviral properties.16 In
one study of extracts from six Hong Kong
brown seaweed species, most of them
inhibited herpes simplex virus types 1
and 2, with very low toxicity to other
cells.17 They
were also moderately effective in
inhibiting respiratory syncytial virus
(RSV).
In fact,
seaweeds are being actively studied in
the hopes of finding new compounds to
treat viral diseases. In one such study,
red and brown seaweed polysaccharides
inhibited viral replication of the
hepatitis C virus,18 while
others have pointed to their diverse
modes of action.
“The
structural diversity and complexity of
marine polysaccharides and their
derivatives contribute to their
antiviral activities in different phases
of many different viral infection
processes,” researchers wrote in the
journal Carbohydrate Research, noting
that seaweed extracts have the ability
to inhibit virus internalization and
uncoating as well as inhibit virus
transcription and replication. Some are
also immunomodulatory.19
In another
study, 16 extracts of British Columbian
seaweeds were investigated and 15 of
them were found to have direct
virus-killing abilities.20
Japan, where
seafood is a dietary staple, had low
initial levels of COVID-19 infection,
particularly in Hokkaido.
Writing in
the Journal of Applied Phycology,
researchers from the University of
Coimbra and Canada’s Verschuren Centre
for Sustainability in Energy and
Environment suggested that there may be
a connection and the low initial rates
“were possibly related to the
traditional and widespread consumption
of seaweed and the regular supply of
iodine in their diet.”21
While cases
later increased, they noted, “These
reports suggest that seaweed helped
Hokkaido populations to reduce contagion
in an initial period, but their
consumption was not a 100% effective
weapon …”22
Seaweed extracts, including
carrageenan, have also been found to
benefit the common cold, which is caused
by different respiratory viruses,
including coronavirus. In a study of
children and adults, a carrageenan nasal
spray reduced the duration of the common
cold while also increasing viral
clearance and reducing relapse of
symptoms.23
The
pharmaceutical company Boehringer
Ingelheim markets a carrageenan-based
nasal spray, but the researchers
questioned why the substantial research
about the antiviral properties of
seaweed extracts appears to have gone
largely unrecognized by Big Pharma
during the COVID-19 pandemic. They
added:24
“Many
species of marine algae contain
significant quantities of complex
structural sulphated polysaccharides
that have been shown to inhibit the
replication of enveloped viruses
including members of the Nidovirales.
Other
compounds, both of red algae (e.g., the
lectin griffithsin), and other sulphated
polysaccharides extracted from green
algae (i.e. ulvans) and brown algae
(i.e. fucoidans) could be potential
antiviral therapeutic agents against
SARS-CoV-2.”
There are many
reasons to add seaweed to your diet,
even aside from its antiviral potential.
It’s an excellent source of iodine,
for starters, which in itself is a
strong weapon against viral infections.
An imbalance of iodine affects your thyroid
function, which in turn affects
many other systems in your body,
including your heart.
Seaweed also
has properties that are useful for lowering
blood pressure. In an
observational study in children, seaweed
consumption was shown to lower diastolic
blood pressure in boys and systolic
blood pressure in girls.25
As for
adults, research published in the
American Journal of Hypertension found
that a preparation made from seaweed
decreased mean blood pressure in 62
middle-aged patients with mild high
blood pressure.26
Seaweed
contains beneficial nutrients as well,
including potassium, calcium, iron and
alginic acid. Alginic acid naturally
protects marine plants from bacteria and
binds to heavy metals in humans, which
makes seaweed a powerful detoxifying
food.
Choosing
seaweed from unpolluted waters is
crucial, as these plants absorb the
contents of the water in which they're
grown. While this is part of what makes
them so nutritious, it can also be their
downfall if sourced from contaminated
waters.
This Dr. Mercola article is just another proof that seaweeds can be very helpful in preventing and treating a viral condition like COVID-19. May we recommend Ocean Treasure? Not only does Ocean Treasure contain 4 red, 4 brown and 1 green seaweeds (9 sea vegetables altogether), but Ocean Treasure also contains concentrated, low sodium sea minerals. With this, you get a good concentration of trace minerals along with sulfated polysaccharides, fucoidans and the hundreds of wonderful phyto-nutrients contained in seaweed.